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Product Name
Transcription Factor 7 Like 1 Rabbit mAb
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Gene ID
83439
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SwissProt ID
Q9HCS4
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Gene Name
TCF7L1
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Alternative Names
Transcription factor 7-like 1; HMG box transcription factor 3; TCF-3; TCF7L1; TCF3
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Background
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB,FC
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Dilution Ratio
WB: 1/500-1/1000 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 63 kDa; Observed MW: 63 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R05-2J4
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human TCF3
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.