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Product Name
Tryptophan 5 Hydroxylase 1 Rabbit mAb
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Gene ID
7166
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SwissProt ID
P17752
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Gene Name
TPH1
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Alternative Names
TPH1; MGC119994; TPRH; TRPH; Tryptophan 5-hydroxylase 1; Tryptophan Hydroxylase
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Background
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin by converting tryptophan to 5-hydroxy-L-tryptophan. Two isoforms of TPH exist: TPH-1 is mainly expressed in the periphery, whereas the expression of TPH-2 is restricted to neuronal cells and the central nervous system. Most of the serotonin found throughout the body is synthesized by TPH-1 in enterochromaffin cells of the gastrointestinal tract. Targeted disruption of the tph1 gene results in low levels of circulating and tissue serotonin.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-P,IP
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/50
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Molecular Weight
Calculated MW: 51 kDa; Observed MW: 51 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R06-2J1
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human TPH1
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.