-
Product Name
DAB2 Rabbit mAb
-
Gene ID
1601
-
SwissProt ID
P98082
-
Gene Name
DAB2
-
Alternative Names
DOC2; DOC-2
-
Background
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
-
Research Field
Signal Transduction
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human
-
Application
WB,IHC-P,IP
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
-
Molecular Weight
Calculated MW: 82 kDa; Observed MW: 96 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R02-4H2
-
Isotype
IgG
-
Immunogen
A synthetic peptide of human DAB2
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.