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Product Name
BMI1 Rabbit mAb
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Gene ID
100532731
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SwissProt ID
P35226
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Gene Name
BMI1
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Alternative Names
BMI1; PCGF4; RNF51; Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51
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Background
The polycomb group (PcG) of proteins contributes to the maintenance of cell identity, stem cell self-renewal, cell cycle regulation, and oncogenesis by maintaining the silenced state of genes that promote cell lineage specification, cell death, and cell-cycle arrest. PcG proteins exist in two complexes that cooperate to maintain long-term gene silencing through epigenetic chromatin modifications. The first complex, EED-EZH2, is recruited to genes by DNA-binding transcription factors and methylates histone H3 on Lys27.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,ICC/IF,IP
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
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Molecular Weight
Calculated MW: 37 kDa; Observed MW: 43 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R08-7A6
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Isotype
IgG
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Immunogen
Recombinant protein of human Bmi1
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.