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Product Name
APC Rabbit mAb
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Gene ID
324
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SwissProt ID
P25054
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Gene Name
APC
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Alternative Names
APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5
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Background
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB,ICC/IF,IP
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
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Molecular Weight
Calculated MW: 312 kDa; Observed MW: 160 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R06-2E4
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Isotype
IgG
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Immunogen
A synthetic peptide of human APC
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.