-
Product Name
TP53BP2 Rabbit mAb
-
Gene ID
7159
-
SwissProt ID
Q13625
-
Gene Name
TP53BP2
-
Alternative Names
53BP2; ASPP2; p53BP2; PPP1R13A; Tp53bp2
-
Background
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
-
Research Field
Cell Biology
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human
-
Application
WB,IHC-P,ICC/IF
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
-
Molecular Weight
Calculated MW: 126 kDa; Observed MW: 150 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R09-1B5
-
Isotype
IgG
-
Immunogen
A synthesized peptide derived from human ASPP2
-
Purification
Affinity Chromatography
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.