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Product Name
Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Rabbit mAb
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Gene ID
51347/57551/9344
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SwissProt ID
Q7L7X3/Q9H2K8/Q9UL54
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Gene Name
TAOK1/TAOK2/TAOK3
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Alternative Names
DPK; JIK; hKFC-A; MAP3K18
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Background
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6.
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Research Field
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-P
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100
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Molecular Weight
Calculated MW: 116 kDa; Observed MW: 105,116,138 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R04-3I5
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Isotype
IgG
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser181 of human TAOK1
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.