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Product Name
HDAC6 Rabbit mAb
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Gene ID
10013
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SwissProt ID
Q9UBN7
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Gene Name
HDAC6
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Alternative Names
HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6
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Background
Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB,IHC-P,ICC/IF,IP
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/50
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Molecular Weight
Calculated MW: 131 kDa; Observed MW: 131-160 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R07-2H6
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human HDAC6
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.