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Product Name
Wnt5a Rabbit mAb
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Gene ID
7474
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SwissProt ID
P41221
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Gene Name
WNT5A
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Alternative Names
WNT5A; Protein Wnt-5a
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Background
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression.
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Research Field
Neuroscience
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB,ICC/IF
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200
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Molecular Weight
Calculated MW: 42 kDa; Observed MW: 45 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R08-4A3
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Isotype
IgG
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Immunogen
A synthetic peptide of human Wnt5a
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.