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Product Name
Nicastrin Rabbit mAb
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Gene ID
23385
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SwissProt ID
Q92542
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Gene Name
NCSTN
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Alternative Names
APH2; Ncstn; NCT; Nicastrin
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Background
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
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Research Field
Neuroscience
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB,ICC/IF
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200
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Molecular Weight
Calculated MW: 78 kDa; Observed MW: 120,140 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R02-8L5
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Nicastrin
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.