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Product Name
LGR5 Rabbit mAb
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Gene ID
8549
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SwissProt ID
O75473
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Gene Name
LGR5
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Alternative Names
FEX; GPR49; GPR67; GRP49; LGR5; HG38; 8
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Background
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,FC,IP
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Dilution Ratio
WB: 1/500-1/1000 IP: 1/50 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 100 kDa; Observed MW: 100 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R01-3D9
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human LGR5/GPR49
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.