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Product Name
Dnmt3b Rabbit mAb
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Gene ID
1789
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SwissProt ID
Q9UBC3
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Gene Name
DNMT3B
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Alternative Names
Dnmt3b; DNA methyltransferase HsaIIIB; DNMT3B
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Background
Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity).
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,ICC/IF
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200
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Molecular Weight
Calculated MW: 96 kDa; Observed MW: 97 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R09-7G6
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Dnmt3b
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.