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Product Name
Phospho-Chk2 (Thr68) Rabbit mAb
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Gene ID
11200
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SwissProt ID
O96017
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Gene Name
CHEK2
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Alternative Names
CHEK2; CHK2; Cds1; Chk2; EC 2.7.11.1; RAD53; kinase Chk2;
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Background
These are known to be preferred sites for phosphorylation by ATM/ATR kinases. After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB,IP
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Dilution Ratio
WB: 1/500-1/1000 IP: 1/50
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Molecular Weight
Calculated MW: 61 kDa;Observed MW:65kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R23-2L-9
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Phospho-Chk2 (T68)
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.