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Product Name
Phospho-GSK3 (alpha + beta)(Tyr216/Tyr279) Rabbit mAb
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Gene ID
2931
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SwissProt ID
P49840
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Gene Name
GSK3A
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Alternative Names
Glycogen synthase kinase-3 alpha; GSK-3 alpha; GSK3A
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Background
GSK3A a proline-directed protein kinase of the GSK family. Implicated in the control of several regulatory proteins including glycogen synthase, Myb, and c-Jun. GSK3 and GSK3 have similar functions. GSK3 phophorylates tau, the principal component of neurofibrillary tangles in Alzheimer disease and is required for maximal production of amyloid plaque peptides by secretase.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-P,ICC/IF,IP
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/100-1/200 IF: 1/50-1/200 IP: 1/50
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Molecular Weight
Calculated MW:51kDa;Observed MW:51kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R47-6P-9
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Phospho-GSK3 (alpha + beta)(Y216 + Y279)
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.