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Product Name
Phospho-MSK1 (Ser376) Rabbit mAb
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Gene ID
9252
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SwissProt ID
O75582
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Gene Name
RPS6KA5
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Alternative Names
90 kDa ribosomal protein S6 kinase polypeptide 5; EC 2.7.11.1; KS6A5; MSPK1; Nuclear mitogen- and stress-activated protein kinase-1; RLPK; RPS6KA5; kinase MSK1; ribosomal protein S6 kinase;
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Background
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Rat
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Application
WB,IHC-P,ICC/IF,IP
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/100-1/200 IF: 1/50-1/200 IP: 1/50
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Molecular Weight
Calculated MW: 90 kDa;Observed MW:80-100kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R84-3U-1
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Phospho-MSK1 (S376)
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.