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Product Name
Phospho-LRRK2 (Ser935) Rabbit mAb
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Gene ID
120892
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SwissProt ID
Q5S007
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Gene Name
LRRK2
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Alternative Names
AURA17;Dardarin; LRRK2; LRRK 2; PARK8; RIPK7; ROCO2;
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Background
The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
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Research Field
Neuroscience
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse
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Application
WB,ICC/IF
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200
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Molecular Weight
Calculated MW:286kDa;Observed MW:286kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R94-3M-6
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Phospho-LRRK2 (S935)
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.