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Product Name
WRN Rabbit mAb
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Gene ID
7486
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SwissProt ID
Q14191
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Gene Name
WRN
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Alternative Names
Exonuclease WRN; RecQ3; RECQL2; RECQL3; Werner syndrome helicase; WRN
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Background
Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 162 kDa; Observed MW: 200 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R03-8U2
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human WRN
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.