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Product Name
PAG1 Rabbit mAb
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Gene ID
55824
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SwissProt ID
Q9NWQ8
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Gene Name
PAG1
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Alternative Names
CBP; Csk binding protein; PAG; PAG1
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Background
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-P,FC,IP
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/50 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 47 kDa; Observed MW: 80 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R02-4H6
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human PAG
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.