-
Product Name
Phospho-MLKL (Ser358) Rabbit mAb
-
Gene ID
197259
-
SwissProt ID
Q8NB16
-
Gene Name
MLKL
-
Alternative Names
MLKL
-
Background
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
-
Research Field
Signal Transduction
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human
-
Application
WB,IHC-P
-
Cited
WB (Mouse)
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100
-
Molecular Weight
Calculated MW: 54 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R02-2I5
-
Isotype
IgG
-
Immunogen
A synthesized peptide derived from human Phospho-MLKL (S358)
-
Purification
Affinity Chromatography
-
Conjugation
Unconjugated
-
Modification
Phosphorylated
-
Form
Liquid
-
Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.