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Product Name
Osteoprotegerin Rabbit mAb
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Gene ID
4982
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SwissProt ID
O00300
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Gene Name
TNFRSF11B
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Alternative Names
OCIF; OPG; Osteoclastogenesis inhibitory factor; Osteoprotegerin; PDB5; TNFRSF11B; TR1;
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Background
Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
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Research Field
Cardiovascular
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
IHC-P,ICC/IF
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Dilution Ratio
IHC: 1/100-1/200 IF: 1/50-1/200
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Molecular Weight
-
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Clonality
Monoclonal Antibody
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Clonality No.
R38-6D-4
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Osteoprotegerin
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.