-
Product Name
NMDAR2A Rabbit mAb
-
Gene ID
14811
-
SwissProt ID
P35436
-
Gene Name
Grin2A
-
Alternative Names
NR2A; GluN2A; NMDAR2A; GluRepsilon1
-
Background
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+. Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B . Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning.
-
Research Field
Neuroscience
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Mouse,Rat
-
Application
WB
-
Dilution Ratio
WB: 1/500-1/1000
-
Molecular Weight
Calculated MW: 165 kDa; Observed MW: 165 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R03-2K3
-
Isotype
IgG
-
Immunogen
Recombinant protein of mouse NMDAR2A
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.