-
Product Name
JAK2 Rabbit mAb
-
Gene ID
3717
-
SwissProt ID
O60674
-
Gene Name
JAK2
-
Alternative Names
JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
-
Background
Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.
-
Research Field
Cell Biology
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human,Mouse
-
Application
WB
-
Cited
WB (Rat)
-
Dilution Ratio
WB: 1/500-1/1000
-
Molecular Weight
Calculated MW: 131 kDa; Observed MW: 131 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R03-1F2
-
Isotype
IgG
-
Immunogen
A synthetic peptide of human JAK2
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.