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Product Name
PRAS40 Rabbit mAb
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Gene ID
84335
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SwissProt ID
Q96B36
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Gene Name
AKT1S1
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Alternative Names
AKT1S1; PRAS40; Proline-rich AKT1 substrate 1; 40 kDa proline-rich AKT substrate
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Background
PRAS40 interacts with Raptor in mTOR complex 1 (mTORC1) in insulin-deprived cells and inhibits the activation of the mTORC1 pathway mediated by the cell cycle protein Rheb. Phosphorylation of PRAS40 by Akt at Thr246 relieves PRAS40 inhibition of mTORC1. mTORC1 in turn phosphorylates PRAS40 at Ser183.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IP
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Dilution Ratio
WB: 1/500-1/1000 IP: 1/50
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Molecular Weight
Calculated MW: 27 kDa; Observed MW: 40 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R06-8A6
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human PRAS40
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.