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Product Name
Phospho-Smad3 (Ser423/425) Rabbit mAb
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Gene ID
4088
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SwissProt ID
P84022
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Gene Name
SMAD3
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Alternative Names
SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3
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Background
Smad3 transcription factor phosphorylated and activated by TGF-beta-type receptors. A receptor-regulated Smad (R-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. In mouse required for establishemnt of the mucosal immune response and proper development of skeleton.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Rat,Hamster
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Application
WB
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Cited
WB (Mouse); IF (Mouse)
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 48 kDa; Observed MW: 52 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R09-6A2
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Isotype
IgG
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser423/Ser425 of human Smad3
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.