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Product Name
HMGB1 Rabbit mAb
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Gene ID
3146
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SwissProt ID
P09429
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Gene Name
HMGB1
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Alternative Names
HMGB1; HMG1; High mobility group protein B1; High mobility group protein 1; HMG-1
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Background
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFκB family, ATF-2 and c-Jun to activate transcription.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-P
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100
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Molecular Weight
Calculated MW: 25 kDa; Observed MW: 25 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R07-2D8
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Isotype
IgG
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Immunogen
A synthetic peptide of human HMGB1
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.