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Product Name
Granzyme B Rabbit mAb
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Gene ID
3002
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SwissProt ID
P10144
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Gene Name
GZMB
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Alternative Names
Granzyme B; Cathepsin G-like 1; CTSGL1; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; SECT; GZMB; CGL1; CSPB; CTLA1; GRB
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Background
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
IHC-P,ICC/IF,IP
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Dilution Ratio
IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/50
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Molecular Weight
-
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Clonality
Monoclonal Antibody
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Clonality No.
R04-6A4
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Granzyme B
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.