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Product Name
Phospho-GCN2 (Thr899) Rabbit mAb
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Gene ID
440275
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SwissProt ID
Q9P2K8
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Gene Name
EIF2AK4
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Alternative Names
GCN2-like protein; GCN2; KIAA1338; EIF2AK4
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Background
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 187 kDa; Observed MW: 220 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R08-4N7
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Phospho-GCN2 (T899)
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.