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Product Name
Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Rabbit mAb
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Gene ID
5595/5594
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SwissProt ID
P27361/P28482
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Gene Name
MAPK1/MAPK3
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Alternative Names
MAPK1/MAPK3
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Background
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB,IHC-P,ICC/IF,FC
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 42,44 kDa; Observed MW: 42,44 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R08-8S3
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Phospho-Erk1 (T202/Y204) + Erk2 (T185/Y187)
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.