-
Product Name
GABA A Receptor alpha 1 Rabbit mAb
-
Gene ID
14394
-
SwissProt ID
P62812
-
Gene Name
Gabra1
-
Alternative Names
Gabra1, Gabra-1
-
Background
GABA A Receptor alpha 1 is a subunit of the GABA A receptor protein. GABA A receptor consists of different combinations of five protein subunits, each produced from a different gene. These subunits form a hole (pore) in the cell membrane through which negatively charged chlorine atoms (chloride ions) can flow. A chemical that transmits signals in the brain (a neurotransmitter) called gamma-amino butyric acid (GABA) attaches to GABA A receptors. Once GABA attaches, the pore formed by the subunits opens, and chloride ions flow across the cell membrane. After infancy, chloride ions flow into the cell through the open pore, which creates an environment in the cell that blocks (inhibits) signaling between neurons. The primary role of GABA in children and adults is to prevent the brain from being overloaded with too many signals. In contrast, in newborns and infants, chloride ions flow out of the cell when the pore is opened, creating an environment that allows signaling between neurons.
-
Research Field
Neuroscience
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Mouse,Rat
-
Application
WB,IHC-P
-
Dilution Ratio
WB：1/500-1/1000 IHC-P：1/50-1/100
-
Molecular Weight
Calculated MW: 52 kDa; Observed MW:52 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R08-6D-3
-
Isotype
IgG
-
Immunogen
Peptide
-
Purification
Protein A
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Liquid in PBS, Glycerol and BSA
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.