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Product Name
β-HydroxyButyryl-Histone H2B (Lys15) Rabbit mAb
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Gene ID
－
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SwissProt ID
P62807
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Gene Name
H2BC4
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Alternative Names
H2BK15bhb, Histone H2B.1 A；Histone H2B.a (H2B/a)；Histone H2B.g (H2B/g)；Histone H2B.h (H2B/h)；Histone H2B.k (H2B/k)；Histone H2B.l (H2B/l)
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Background
Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, etc. β-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone mark that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin induced diabetic ketoacidosis. Histone β-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB
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Dilution Ratio
WB：1/500-1/1000
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
R09-9T-1
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Isotype
IgG
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Immunogen
Peptide
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Purification
Protein A
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Conjugation
Unconjugated
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Modification
β-Hydroxybutyrylated
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Form
Liquid
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Buffer System
Liquid in PBS, Glycerol and BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.