-
Product Name
Crotonyl-Histone H2B (Lys11) Rabbit mAb
-
Gene ID
-
-
SwissProt ID
P62807
-
Gene Name
H2BC4
-
Alternative Names
H2BK11cr, Histone H2B.1 A;Histone H2B.a (H2B/a);Histone H2B.g (H2B/g);Histone H2B.h (H2B/h);Histone H2B.k (H2B/k);Histone H2B.l (H2B/l)
-
Background
Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Crotonylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine crotonylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine crotonylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and mouse male
germ cell genomes, histone crotonylation marks either active promoters or potential enhancers. Crotonylation of histone H2B at Lys11 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.
-
Research Field
Epigenetics and Nuclear Signaling
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human,Mouse,Rat
-
Application
WB
-
Dilution Ratio
WB:1/500-1/1000
-
Molecular Weight
-
-
Clonality
Monoclonal Antibody
-
Clonality No.
R07-8T-4
-
Isotype
IgG
-
Immunogen
Peptide
-
Purification
Protein A
-
Conjugation
Unconjugated
-
Modification
Crotonylated
-
Form
Liquid
-
Buffer System
Liquid in PBS, Glycerol and BSA
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.