产品详情
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Product Name
MADH7/SMAD7 Rabbit mAb
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Gene ID
4092
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SwissProt ID
O15105
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Gene Name
SMAD7
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Alternative Names
MADH8
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Background
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3).
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB
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Dilution Ratio
WB:1/500-1/1000
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Molecular Weight
Calculated MW: 46 kDa; Observed MW:50 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R09-1T-3
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Isotype
IgG
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Immunogen
Peptide
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Purification
Protein A
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS, Glycerol and BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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