货号： R10070
别名： DRY6, CD196, CKRL3, CMKBR6, GPR29, STRL22
应用： WB,IHC-P
反应种属： Human
目录价格：
RMB(含税报价)
数量： - + （库存件）
查看代理商 预计货期：3-4个工作日 说明书PDF
产品详情
  • Product Name
    CCR6 Rabbit mAb
  • Gene ID
    1235
  • SwissProt ID
    P51684
  • Gene Name
    CCR6
  • Alternative Names
    DRY6, CD196, CKRL3, CMKBR6, GPR29, STRL22
  • Background
    Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma.
  • Research Field
    Immunology
  • Product Categories
    Primary antibody
  • Host
    Rabbit
  • Reactivity
    Human
  • Application
    WB,IHC-P
  • Dilution Ratio
    WB：1/500-1/1000 IHC-P：1/50-1/100
  • Molecular Weight
    Calculated MW: 42 kDa; Observed MW:42 kDa
  • Clonality
    Monoclonal Antibody
  • Clonality No.
    R06-9I-5
  • Isotype
    IgG
  • Immunogen
    Peptide
  • Purification
    Protein A
  • Conjugation
    Unconjugated
  • Modification
    Unmodified
  • Form
    Liquid
  • Buffer System
    Liquid in PBS, Glycerol and BSA
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。
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