-
Product Name
CSF1R Rabbit mAb
-
Gene ID
1436
-
SwissProt ID
P07333
-
Gene Name
CSF1R
-
Alternative Names
CSF1R; FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD antigen CD115
-
Background
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
-
Research Field
Cardiovascular
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human
-
Application
FC,ELISA
-
Dilution Ratio
FC: 1/50-1/100 ELISA: 1/10000
-
Molecular Weight
-
-
Clonality
Monoclonal Antibody
-
Clonality No.
R05-4T-3
-
Isotype
IgG
-
Immunogen
Recombinant human CSF1R protein
-
Purification
Affinity Chromatography
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Lyophilized
-
Buffer System
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
-
Storage
Store at -20°C to -80°C for 12 months in lyophilized form.