产品详情
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Product Name
Human IL-21 Protein
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Gene ID
59067
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SwissProt ID
Q9HBE4
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Gene Name
IL21
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Alternative Names
Interleukin-21; IL-21; Za11
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Background
Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation, suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
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Research Field
Immunology
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Product Categories
Protein
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Host
E-coli
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Reactivity
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Application
Functional Assay
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Dilution Ratio
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Molecular Weight
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Clonality
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Clonality No.
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Isotype
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Immunogen
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Immunogen Alternative Names
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
His
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Form
lyophilized
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Buffer System
0.01M PBS, pH 7.2
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Storage
Aliquot and store at -80°C for long term. Avoid freeze/thaw cycles.
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Target
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应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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