产品详情
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Product Name
Mouse IL-1 beta Protein
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Gene ID
16176
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SwissProt ID
P10749
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Gene Name
Il1b
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Alternative Names
Il1b; Interleukin-1 beta; IL-1 beta
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Background
Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
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Research Field
Immunology
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Product Categories
Protein
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Host
E-coli
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Reactivity
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Application
Functional Assay
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Dilution Ratio
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Molecular Weight
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Clonality
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Clonality No.
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Isotype
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Immunogen
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Immunogen Alternative Names
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
His
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Form
lyophilized
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Buffer System
0.01M PBS, pH 7.2
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Storage
Aliquot and store at -80°C for long term. Avoid freeze/thaw cycles.
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Target
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应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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