产品详情
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Product Name
Fibrinogen Rabbit mAb, unconjugated, detector
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Gene ID
2243
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SwissProt ID
P02671
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Gene Name
FGA
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Alternative Names
Fibrinogen alpha chain
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Background
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
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Research Field
Cardiovascular
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Product Categories
Antibody Pair
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Host
Rabbit
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Reactivity
Human
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Application
ELISA
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Dilution Ratio
Determined by end user
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
R04-8Q-8
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Isotype
IgG
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Immunogen
Recombinant protein
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Purification
Affinity Purification
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
0.01M PBS, pH 7.2
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Storage
Store at 4°C for at least 12 months. Avoid freeze/thaw cycles
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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