产品详情
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Product Name
Visfatin Rabbit mAb, unconjugated, detector
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Gene ID
10135
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SwissProt ID
P43490
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Gene Name
NAMPT
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Alternative Names
Pre-B-cell colony-enhancing factor 1 (Pre-B cell-enhancing factor);Visfatin
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Background
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).
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Research Field
Cardiovascular
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Product Categories
Antibody Pair
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Host
Rabbit
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Reactivity
Human
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Application
ELISA
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Dilution Ratio
Determined by end user
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Molecular Weight
-
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Clonality
Monoclonal Antibody
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Clonality No.
R04-4M-1
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Isotype
IgG
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Immunogen
Recombinant protein
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Purification
Affinity Purification
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
0.01M PBS, pH 7.2
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Storage
Store at 4°C for at least 12 months. Avoid freeze/thaw cycles
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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