产品详情
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Product Name
CD4 Rabbit mAb, capture
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Gene ID
920
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SwissProt ID
P01730
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Gene Name
CD4
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Alternative Names
CD4
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Background
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
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Research Field
Immunology
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Product Categories
Antibody Pair
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Host
Rabbit
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Reactivity
Human
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Application
ELISA
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Dilution Ratio
Determined by end user
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
R01-2M-8
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Isotype
IgG
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Immunogen
Recombinant protein
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Purification
Affinity Purification
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
0.01M PBS, pH 7.2
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Storage
Store at 4°C for at least 12 months. Avoid freeze/thaw cycles
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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