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货号： RB20197UD

别名： Flt-4, Vegfr3,Flt4,Vascular endothelial growth factor receptor 3,VEGFR-3,Fms-like tyrosine kinase 4 (FLT-4),Tyrosine-protein kinase receptor FLT4

应用： ELISA

反应种属： Human

目录价格：

RMB(含税报价)

数量： - + （库存件）

查看代理商预计货期：3-4个工作日说明书PDF

产品详情

Product Name

VEGF Receptor 3 Rabbit mAb, unconjugated, detector
Gene ID

2324
SwissProt ID

P35916
Gene Name

FLT4
Alternative Names

Flt-4, Vegfr3,Flt4,Vascular endothelial growth factor receptor 3,VEGFR-3,Fms-like tyrosine kinase 4 (FLT-4),Tyrosine-protein kinase receptor FLT4
Background

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
Research Field

Cardiovascular
Product Categories

Antibody Pair
Host

Rabbit
Reactivity

Human
Application

ELISA
Dilution Ratio

Determined by end user
Molecular Weight

-
Clonality

Monoclonal Antibody
Clonality No.

R12-4S-1
Isotype

IgG
Immunogen

Recombinant protein
Purification

Affinity Purified
Conjugation

Unconjugated
Modification

Unmodified
Form

Liquid
Buffer System

0.01M PBS, pH 7.2
Storage

Store at 4°C for at least 12 months. Avoid freeze/thaw cycles

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应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。

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