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货号： R24402

别名： Gapd

应用： WB,IHC-F,IHC-P,ICC/IF,IP

反应种属： Human,Mouse,Rat

目录价格：

RMB(含税报价)

数量： - + （库存件）

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产品详情

Product Name

GAPDH Rabbit mAb
Gene ID

14433
SwissProt ID

P16858
Gene Name

GAPDH
Alternative Names

Gapd
Background

Swiss-Prot Acc.P16858.Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
Research Field

Neuroscience
Product Categories

Loading Control antibody
Host

Rabbit
Reactivity

Human,Mouse,Rat
Application

WB,IHC-F,IHC-P,ICC/IF,IP
Dilution Ratio

WB: 1/2000 IHC: 1/200 ICC/IF: 1/100 IP: 1/20
Molecular Weight

Calculated MW: 36 kDa; Observed MW: 36 kDa
Clonality

Monoclonal Antibody
Clonality No.

R03-5G5
Isotype

Rabbit IgG
Immunogen

Recombinant protein of human GAPDH
Purification

Affinity Purified
Conjugation

Unconjugated
Modification

Unmodified
Form

Liquid
Buffer System

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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验证详情

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应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。

引用文献更多完整详情

标题： LncRNA GACAT3 promotes esophageal squamous cell carcinoma progression through regulation of miR-149/FOXM1

样本种属： Human

杂志： Cancer Cell International

应用： WB

IF： 5.722

文献链接

标题： Integrin αEβ7 is involved in the intestinal barrier injury of sepsis

样本种属： Rat

杂志： Aging-US

应用： WB

IF： 5.682