-
Product Name
hGCGR full length protein-synthetic nanodisc
-
Gene ID
2642
-
SwissProt ID
P47871
-
Gene Name
GCGR
-
Alternative Names
GGR; GL-R; MVAH
-
Background
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
-
Research Field
Signal Transduction
-
Product Categories
Full Length Transmembrane Proteins
-
Host
HEK293 Cells
-
Reactivity
Human
-
Application
-
Dilution Ratio
-
Molecular Weight
The human full length GCGR protein has a MW of 54.0 kDa
-
Form
Freeze-dried powder
-
Buffer System
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
-
Storage
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
-
Target
GCGR