-
Product Name
hCXCR2 full length protein-synthetic nanodisc
-
Gene ID
3579
-
SwissProt ID
P25025
-
Gene Name
CXCR2,IL8RB
-
Alternative Names
CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB
-
Background
The protein is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
-
Research Field
Signal Transduction
-
Product Categories
Full Length Transmembrane Proteins
-
Host
HEK293 Cells
-
Reactivity
Human
-
Application
-
Dilution Ratio
-
Molecular Weight
The human full length CXCR2 protein has a MW of 40.8 kDa
-
Form
Freeze-dried powder
-
Buffer System
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
-
Storage
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
-
Target
CXCR2