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Product Name
hCCR7 full length protein-synthetic nanodisc
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Gene ID
1236
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SwissProt ID
P32248
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Gene Name
CCR7,CMKBR7, EBI1, EVI1
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Alternative Names
BLR2; CC-CKR-7; CCR-7; CD197; CDw197; CMKBR7; EBI1
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Background
The protein is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis.
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Research Field
Signal Transduction
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Product Categories
Full Length Transmembrane Proteins
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Host
HEK293 Cells
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Reactivity
Human
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Application
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Dilution Ratio
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Molecular Weight
The human full length CCR7 protein has a MW of 42.9 kDa
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Form
Freeze-dried powder
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Buffer System
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
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Storage
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Target
CCR7