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Product Name
hCCR8 full length protein-synthetic nanodisc
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Gene ID
1237
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SwissProt ID
P51685
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Gene Name
CCR8,CKRL1, CMKBR8, CMKBRL2
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Alternative Names
CC-CKR-8;CCR-8;CDw198;CKRL1;CMKBR8;CMKBRL2;CY6;GPRCY6;TER1
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Background
A member of the beta chemokine receptor family,which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309,thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically,this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.
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Research Field
Signal Transduction
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Product Categories
Full Length Transmembrane Proteins
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Host
HEK293 Cells
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Reactivity
Human
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Application
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Dilution Ratio
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Molecular Weight
The human full length CCR8 Protein has a MW of 40.7 kDa
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Form
Freeze-dried powder
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Buffer System
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
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Storage
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Target
CCR8