-
Product Name
hAGRL1 full length protein-synthetic nanodisc
-
Gene ID
22859
-
SwissProt ID
O94910
-
Gene Name
ADGRL1,KIAA0821,LEC2,LPHN1
-
Background
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
-
Research Field
Epigenetics & Nuclear Signaling
-
Product Categories
Full Length Transmembrane Proteins
-
Host
HEK293 Cells
-
Reactivity
Human
-
Application
-
Dilution Ratio
-
Molecular Weight
The human full length AGRL1 protein has a MW of 162.7kDa
-
Form
Freeze-dried powder
-
Buffer System
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
-
Storage
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
-
Target
AGRL1