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Product Name
[KD] Phospho-CDC6 (Ser106) Rabbit mAb
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Gene ID
990
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SwissProt ID
Q99741
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Gene Name
CDC6
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Alternative Names
CDC6; CDC18L; Cell division control protein 6 homolog; CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6
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Background
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.Cdc6 has recently been shown to play an important role in the intra-S-phase p21 Waf1/Cip1-dependent DNA damage response. Both cdc6 and CDT1 are degraded by the ubiquitin proteasome pathway in response to DNA damage associated with re-replication.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
KO/KD validated
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Host
Rabbit
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Reactivity
Human,Rat
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 63 kDa; Observed MW: 63 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R01-0F2
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Isotype
IgG
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser106 of human Cdc6
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.