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Product Name
[KD] Phospho-Presenilin 1 (Ser310) Rabbit mAb
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Gene ID
5663
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SwissProt ID
P49768
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Gene Name
PSEN1
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Alternative Names
PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182
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Background
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity.
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Research Field
Neuroscience
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Product Categories
KO/KD validated
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Host
Rabbit
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Reactivity
Human
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 53 kDa; Observed MW: 22 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R07-6E3
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Isotype
IgG
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser310 of human Presenilin 1
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.