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Product Name
[KO] Phospho-PKR (Thr451) Rabbit mAb
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Gene ID
5610
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SwissProt ID
P19525
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Gene Name
EIF2AK2
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Alternative Names
EIF2AK2; PKR; PRKR; Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k
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Background
PKR a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis.
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Research Field
Signal Transduction
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Product Categories
KO/KD validated
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Host
Rabbit
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Reactivity
Human
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 62 kDa; Observed MW: 74 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R08-2G5
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Isotype
IgG
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Thr451 of human PKR
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.