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Product Name
[KO] NUMB Rabbit mAb
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Gene ID
8650
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SwissProt ID
P49757
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Gene Name
NUMB
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Alternative Names
NUMB; Protein numb homolog; h-Numb; Protein S171
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Background
Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch. The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates. The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling.
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Research Field
Neuroscience
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Product Categories
KO/KD validated
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-P,IP
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
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Molecular Weight
Calculated MW: 71 kDa; Observed MW: 71 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R09-2I5
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Isotype
IgG
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Immunogen
Recombinant protein of human NUMB
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.